Retinoid storage in hepatic stellate cells

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

UNLABELLED Hepatic stellate cell (HSC) lipid droplets are specialized organelles for the storage of retinoid, accounting for 50-60% of all retinoid present in the body. When HSCs activate, retinyl ester levels progressively decrease and the lipid droplets are lost. The objective of this study was to determine if the HSC population in a healthy, uninjured liver demonstrates heterogeneity in its ...

Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells

Hepatic stellate cells (HSCs) are retinoid storing cells in the liver: The retinoid content of those cells changes depending on nutrition and stress level. There are also differences with regard to a HSC's anatomical position in the liver. Up to now, retinoid levels were only accessible from bulk measurements of tissue homogenates or cell extracts. Unfortunately, they do not account for the int...

Hepatic Stellate Cells Preferentially Induce

Decreased Capacity for Vitamin A Storage in Hepatic Stellate Cells for Arctic Animals

Email: Haruki Senoo* [email protected]; Kenjiro Wake [email protected]; Heidi L Wold [email protected]; Nobuyo Higashi [email protected]; Katsuyuki Imai [email protected]; Jan Øivind Moskaug [email protected]; Naosuke Kojima [email protected]; Mitsutaka Miura [email protected]; Takeya Sato [email protected]; Mitsuru Sato [email protected]...

PPAR Gamma and Hepatic Stellate Cells

Activation of Hepatic stellate cells (HSC) in fibrogenesis involves distinct morphological and biochemical changes. This activation requires the coordinated changes in activity of several transcription factors. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one such factor whose activity is decreased in activated HSC. PPAR gamma ligands suppress several markers of HSC activati...